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Part One: Anatomy, Physiology, Classifications, Demographics

Chapter 1           Breast Anatomy

Chapter 2           Chronological Breast Development

Chapter 3           Pregnancy, Lactation and their Relationship to Breast Cancer

Chapter 4           Noncancerous Pathophysiology of the Breast

  • Nonproliferative Changes

  • Proliferative Changes without Atypia

  • Proliferative Changes with Atypia

  • Infection or Mastitis

  • Mastitis without Lactation

  • Mammary Fat Necrosis

  • Granular Cell Tumor

  • Hamartoma

Chapter 5           Types of Breast Carcinoma

  • Intraductal Carcinoma

    • Ductal Carcinoma in situ (DCIS)

      • DCIS Classifications

      • DCIS Increased Incidence

      • DCIS Invasive Potential

      • DCIS Nomenclature Controversy

      • Low Grade DCIS (LGDCIS)

      • High Grade DCIS (HGDCIS)

      • DCIS Treatment

    • Invasive Ductal Carcinoma (IDC)

  • Lobular Carcinoma

    • Lobular Carcinoma in situ (LCIS)

      • Observation for LCIS

      • Hormone Management for LCIS

    • Invasive Lobular Carcinoma (ILC)

  • Inflammatory Breast Carcinoma

  • Inflammatory Breast Carcinoma Treatment

  • Paget's Disease

  • Paget’s Disease Treatment

  • Phylloides Tumors

  • Breast Cancer Cell Lines: their origins and properties simplified

Chapter 6           Cell Physiology and Voltage

  • Acid Base Balance and its Relationship to Cellular Voltage

  • Free Radical Pathology and Cellular Energy

  • Adenosine-5'-triphosphate

  • Overview of the Citric Acid Cycle or Krebs Cycle

  • HEEL - Bio-Catalysts of the Citric Acid Cycle

  • Administering the Bio-Catalysts

Chapter 7           Cellular Pathology and the Extracellular Matrix

  • pH and the Extra-cellular Matrix

  • Development of Cancerous Cells and Genetic Abnormalities

  • Angiogenesis and the Extracellular Matrix

  • Matrix Metalloproteases (MMP) and Metastasis

  • Insulin-Like Growth Factors

Chapter 8           Tyrosine Kinase Cellular Receptors and Breast Cancer Pathophysiology

  • Pharmaceutical Manipulation of TK Receptors

  • Sea Cucumber and Frondoside A

Chapter 9           Overview of Immune Regulation

  • The Innate Immune System

  • The Adaptive Immune System

  • Gc-MAF (Group Complement Macrophage Activating Factor)

  • Nutrients and Immunity

  • Immune Surveillance or Immunoediting

    • Immunoediting - Elimination

    • Immunoediting - Equilibrium

    • Immunoediting - Escape

Chapter 10          Overview of Metastasis

  • E-Cadherin Loss

  • Surgery and the Potential of Metastasis

  • Galectins and Metastasis

  • Modified Citrus Pectin (MCP) and Galectins

Chapter 11          Medical Records and Understanding Pathology Reports

  • Pathology Reports

  • Cell Type

  • Size

  • Histological Grade  – The Nottingham Histologic Score System

    • Glandular (Acinar)/Tubular Differentiation

    • Nuclear Polymorphism

    • Mitotic Count

  • DNA Cytometry – Aneuploid versus Diploid Status

  • S-phase Fraction (SPF)

  • Ki-67 Labeling Index

  • E- cadherin

  • Estrogen and Progesterone Receptor Status

  • Tyrosine Kinase (HER2/neu) Receptor Status

  • Triple Negative Breast Cancer (TNBC)

  • Lymph Node Status

  • Microscopic Vascular Invasion

  • Tumor Margins

Chapter 12          Prognosis

Chapter 13          Conventional Oncological Staging Systems

Chapter 14          Staging Illness: Phases of Homotoxicosis as Described by Hans-Heinrich Reckeweg

  • Excretion Phase

  • Reactive Phase

  • Deposition Phase

  • Impregnation Phase

  • Degeneration Phase

  • Neoplastic Phase

Chapter 15          Statistics and Demographics of Breast Cancer

  • World Wide Breast Cancer Statistics

  • United States Breast Cancer Statistics

  • Survival Statistics

  • Etiology Statistics


Part Two: Etiology of Breast Cancer

Chapter 16          Radiation and Cancer

  • Ionizing Radiation

    • The Linear No-Threshold Model (LNT)

    • Nuclear Weapons Testing - Studies of Atomic Bomb Survivors

    • Workers and Communities Exposed to Nuclear Power-Plant Reactor Meltdowns

    • Medical Radiation Risks

    • Ionizing Radiation Effects

    • Brown Algae as Protective from Radioactivity

  • Non-Ionizing Radiation

    • Extremely Low-Frequency Electromagnetic Fields (ELF-EMF) and Breast Cancer Occurrence

    • Cell Phones and Cell Towers

Chapter 17          Estrogen and Progesterone’s Relationship to Breast Cancer

  • Estrogen Physiology

  • Types of Estrogen

  • Sites of Estrogen Biosynthesis

  • Estrogen Metabolism

  • Estriol and the Estrogen Quotient

  • Oral Estrogen vs Transdermal/Vaginal Transmucosal

  • Xenoestrogens

  • The Women’s Health Initiative (WHI) Study

  • Provera (medroxyprogesterone acetate)

  • Premarin and Equine Estrogens

  • Oral Contraceptives

  • Infertility Treatment Drugs

  • Bioidentical Hormones and Progesterone

Chapter 18          Environmental Toxicity and Tobacco

  • Endocrine-Disrupting Compounds

  • Polycyclic Aromatic Hydrocarbons

  • Organochlorines

  • Parabens

  • Benzene

  • Phthalates

  • Avoiding Phthalates

  • Polyvinylchloride (PVC)

  • Formaldehyde

  • Styrene

  • Cosmetics and Breast Cancer

  • Carcinogenic and Potentially Carcinogenic Toxic Elements

  • Tobacco

Chapter 19          Food Toxins and Breast Cancer

  • Food Packaging and Bisphenol A (BPA)

  • Ways to Avoid Food Packaging Toxins

  • Herbicides, Insecticides and Food Carcinogens

    • Triazine Herbicides

    • Agricultural Insecticides - Dieldrin and Aldrin

    • Household Insecticides

    • Heptachlor

    • Dieldrin and Aldrin

  • Ways to Avoid Herbicides, Insecticides and Toxins in Food

  • Genetically Modified Organisms (GMO)

  • Carcinogenic Hormones in Meat and Milk

    • Zeranol (α-zearalanol)

    • Recombinant Bovine Somatotrophin (rBST) or (rBGH)

Chapter 20          Mechanistic Theory in Conventional Medicine

Chapter 21          Biology of the Psyche

Chapter 22          Dr. Ryke Geerd Hamer’s Theories of Cancer Causation

  • Dirk Hamer Syndrome (DHS)

  • Phases of Illness

  • Embryonic Tissue Correspondence

  • Laterality

  • Metastasis

Chapter 23          The Pineal Gland and Melatonin’s Relationship to Breast Cancer

Chapter 24          Dental Mercury Amalgams and their Health Consequences

  • Dental Mercury Exposure and Body Burden

  • Current Politics of Dental Mercury

  • Dental Mercury Toxicology Research

  • Pathophysiology of Dental Mercury

  • Oral Galvanicity

Chapter 25          Periodontal Infections, Root Canal Treated Teeth and Dental Cavitations

  • Oral Toxicology and Cancer

  • Periodontal Disease and Systemic Disease

  • Root Canal Treatments and their Potential Health Consequences

  • Cavitations and Osteonecrosis of the Jaw (ONJ)

    • Cavitation Causes and ONJ

    • Cavitation and Periapical Periodontitis Diagnosis

    • Cavitation Treatment


Chapter 26          Hereditary Genetic and Genomic Factors in Breast Cancer

  • BRCA 1 and BRCA 2

    • BRCA Testing

    • Bilateral Prophylactic Mastectomy and Prophylactic Salpingo-Oophorectomy

    • Options Other than Surgery for BRCA Mutations

  • PALB2

  • Tumor Protein 53 (TP53, p53)

  • Single Nucleotide Polymorphisms (SNPs) that Affect Estrogen Biosynthesis and Metabolism

    • Cytochrome P450 1A1 and Cytochrome P450 1B1 Enzymes and Their SNPs

      • CYP1A1 (Cytochrome P450 1A1 - Polymorphisms: Msp 1, I462V)

      • CYP1B1 (Cytochrome P450 1B1 - Polymorphism: V432L)

    • Phase II-Conjugating Enzymes and Their SNPs

      • COMT (Catechol-O-methyltransferase - Polymorphism: Val158Met)

      • GST (M1 and P1) (Glutathione S-transferase - GSTP1 polymorphisms: Ile105Val, A114V)

Chapter 27          Putting Etiology all Together


Part Three: Diagnostic Techniques

Chapter 28 Breast Examination – Self- Breast Exam Technique

Chapter 29 Laboratory Testing

  • Cytological Testing - HALO Mamo Cito Test

  • Toxicological Testing

  • Nutritional Testing

  • Hormonal Testing

  • Genetic Testing

    • HER-2/neu “Human Epidermal Growth Factor Receptor 2"

    • MammaPrint

    • Oncotype DX

    • Breast Cancer Gene Expression Ratio

    • S-phase Fraction

  • Antigen/Antibody Testing

    • Carcinoembryonic antigen (CEA)

    • Cancer antigen 15-3

    • Cancer antigen 125 or CA125

    • Ki-67 Antigen

Chapter 30 Breast Biopsy

  • Fine Needle Aspiration Biopsy

  • Core Biopsy

  • Vacuum Assisted Core Biopsy

  • Open Surgical Biopsy

  • Percutaneous Needle Biopsy Controversy – Is it invasive?


 Chapter 31 Imaging Diagnostics of the Breast

  • Mammograms

    • When Does the Risk Out-Weigh the Benefit?

    • Mammography and Age

    • False Negatives

    • False Positives

    • Revising Mammography Guidelines

    • Newer Mammography Machines: Are they better?

  • Sonomammography (Breast Ultrasound)

  • Magnetic Resonance Imaging (MRI) of the Breast

  • Molecular Breast Imaging (MBI)

  • Diaphanography

  • Infrared Thermography Imaging

  • Positron Emission Tomography (PET)

Chapter 31 Contact Regulation Thermography (CRT)


Part Four:  Politics of Cancer

Chapter 33 The Cancer Industry

  • A Brief History of the Medical Industry in the United States

  • Financial Burden of Breast Cancer

  • Financial Funding of Cancer

  • Limitations and Corruptions of the Patent Process

  • The Avoidance of Natural Non-toxic Therapies and Non-acknowledgement of Environmental Causes

  • Research Bias and Conflicts of Interest

  • Chemotherapy Concessions and Late Stage Use of Chemotherapy

  • Cancer Industry Corporation Misdeeds and Wrongdoings

  • The War on Cancer

  • Increasing Treatment Cost

  • Purchasing Medications from Overseas

  • The National Cancer Institute and American Cancer Society

Chapter 34 Parkinson's Law and its Relationship to the Cancer Industry


Part Five: Conventional Breast Cancer Treatment

Chapter 35 Surgery

  • Lumpectomy

    • Lumpectomy and Radiation Therapy

    • Complications of Lumpectomy plus Irradiation:

    • Lumpectomy radiation and various forms of cytotoxic chemotherapy and/or estrogen blocking drugs

  • Mastectomy and Types of Mastectomy

  • Mastectomy Postoperative Care

  • Lymphatic Evaluation

    • Sentinel Lymph Node Biopsy (SLNB)

    • Axillary Lymph Node Dissection (ALND)

  • Timing of the Surgery

  • Avoiding Opiate Narcotics after Surgery

Chapter 36 Reconstructive Surgery and Breast Implants

  • Tissue Expansion Technique

  • Breast Implants

    • Saline-filled

    • Silicone gel-filled

    • Breast Implant Safety

    • Implant Rupture

    • Silicone’s Effect on the Immune System

  • Muscle Flap Reconstruction

    • TRAM (Transverse Rectus Abdominis Muscle) Flap

      • Pedicle TRAM Flap

      • Free TRAM Flap

    • DIEP Flap (Deep Inferior Epigastric Perforator Flap)

    • Latissimus Dorsi Flap or LD Flap

    • Gluteal Free Flap or GAP Flap

    • Inner Thigh or TUG flap

  • Final Stages of Breast Reconstruction

Chapter 37 Conventional Hormone Therapy

  • Selective Estrogen-Receptor Modulators (SERMs)

    • Tamoxifen Citrate (Nolvadex)

    • Raloxifene (Evista)

    • Toremifene citrate (Fareston)

    • Fulvestrant (Faslodex)

  • Aromatase Inhibitors

    • Exemestane

    • Letrozole

    • Anastrozole

  • Aromatase Inhibitor Side Effects

Chapter 38 Natural Aromatase Inhibitors

  • White Button Mushroom (Agaricus bisporus)

  • Flavonoids as Aromatase Inhibitors

    • Chrysin  

    • Quercetin

    • Apigenin  

  • Resveratrol

  • Oleuropein

Chapter 39 Biologic Response Modifiers and other Palliative Drugs

  • Herceptin (trastuzumab)

  • Kadcyla (ado-trastuzumab emtansine)

  • Tykerb (lapatinib)

  • Bisphosphonates

  • Xgeva (Denosumab)

Chapter 40 Cytotoxic Chemotherapy

  • Goals of Cytotoxic Chemotherapy

  • Mechanisms of Cytotoxic Chemotherapy

  • Cytotoxic Chemotherapy Resistance

  • Clinical Outcomes in Early Breast Cancer

  • Clinical Outcomes in Advanced Metastatic Breast Cancer

  • Cytotoxic Chemotherapy Side Effects

  • Types of Cytotoxic Chemotherapy used in Breast Cancer Treatment

    • Anthrancyclines

      • Doxorubicin (Adriamycin)

      • Epirubicin

  • Alkylating Agents

    • Cyclophosphamide (Cytoxan)

    • Thiotepa (triethylene thiophosphoramide)

  • Antimetabolites

    • Gemcitabine

    • Luorouracil (5FU or 5-Fluorouracil)

    • Capecitabine (Xeloda)

  • Taxanes

    • Paclitaxel (Taxol, Onxol)

    • Docetaxel (Taxotere)

  • Non-Taxane Microtubule Inhibitor - Eribulin mesylate (Halaven)

  • Antifolate - Methotrexate

  • MTHFR Gene Variations, Methylation Defects and Folate Supplementation during Antifolate Chemotherapy

  • Drugs Used for Bone Marrow Suppression Side Effects

    • Neupogen (filgrastim)

    • Neulasta (pegfilgrastim)

    • Epoetin alfa (Procrit; Epogen)

  • The Future of Cytotoxic Chemotherapy

Chapter 41 Cell Culture Drug Resistance Testing and Weisenthal Cytometric Profiling

  • Cell Culture Drug Resistance Tests (CCDRT)

  • Opposition of Cell Culture Drug Resistance Tests

  • Clinical Studies of Cell Culture Drug Resistance Tests

  • Weisenthal Cytometric Profiling

Chapter 42 Insulin Potentiated Therapy (IPT)

  • Insulin Potentiated Therapy Mechanism of Action

  • History of Insulin Potentiation Therapy

  • Insulin Potentiation Therapy Research

Chapter 43 Radiation Therapy

  • Physiological Effects of Radiation Therapy

  • Radiation Therapy Efficacy

  • Types of Radiation Therapy Techniques

    • External Beam Radiation Therapy (EBRT)

    • Intensity Modulated Radiation Therapy (IMRT)

    • Brachytherapy

      • High-dose rate (HDR) brachytherapy

      • MammoSite® brachytherapy

      • Low-Dose Rate (LDR) Brachytherapy

      • Low-Dose Rate (LDR) Brachytherapy

    • Proton Beam Radiation Therapy

    • CyberKnife®

  • Strategies that Aid Radiation Therapy


Part Six: Complementary and Alternative Medicine (CAM) and European Biological Regulatory Medicine

Chapter 44 Immunotherapy Therapy: Thymus and Spleen Peptides; Gc-MAF (Gc-Macrophage Activating Factor) and PNC 27

  • Thymus Extracts and Peptides

  • History of Thymus Therapy

  • Commercial Purified Thymus Extracts (pTE) and Thymic Peptide Preparations

    • Thymex-L

    • TFX-Thymomodulin

    • Thymus Peptide C

    • Thymus Peptide M (LUPEX)

  • Spleen Peptides

  • Commercial Spleen Peptides Preparations

  • Group Complement Macrophage Activating Factor (Gc-MAF)

  • Alpha-N-acetyl-galactosaminidase

  • Gc-MAF Immunotherapy

  • Gc-MAF Methods and Timing of Administration

  • Monitoring Gc-MAF Treatment

  • Gc-MAF Side Effects

  • Colostrum and Immunity

  • Colostrum MAF

  • PNC-27 Peptide Therapy

Chapter 45 Medicinal Mushrooms

  • Coriolus versicolor (Trametes versicolor)

  • Grifola frondosa

  • Ganoderma lucidum

  • Agaricus blazei Murill

  • Inonotus obliquus

  • Medicinal Mushrooms in Medicine


Chapter 46 Mistletoe Therapy

Chapter 47 Paw Paw (Asimina triloba and Related Species)

Chapter 48 Amygdalin

Chapter 49 Proteolytic Enzyme Therapy

Chapter 50 Oxidative Therapy Using Ozone

Chapter 51 Ultraviolet Blood Irradiation; Photoluminescence Therapy

Chapter 52 Photodynamic Therapy, Sonodynamic Therapy and Sono-Photodynamic Therapy

Chapter 53 Hyperthermia

Chapter 54 Detoxification Therapies


Chapter 55 Milieu or Terrain Treatment (Tissue Alkalinization)

Chapter 56 Traditional Chinese Medicine and Breast Cancer

Chapter 57 Dichloroacetic acid (DCA) - A Promising Compound

Part Seven: Nutrition and Breast Cancer

Chapter 58 Nutritional Approaches to Cancer

Chapter 59 Catabolic Wasting and Nutritional Intervention

Chapter 60 Soy Products

Chapter 61 Unique Hormones and Prohormones

Chapter 62 Antioxidants

Chapter 63 Estrogen Regulatory Substances

Chapter 64 Important Minerals


Part Eight: Maintaining Physical Fitness

Chapter 65 Yoga


Part Nine: Biological Dentistry

Chapter 66 Biocompatible Materials and Mercury Amalgam Removal

Chapter 67 Non-vital Teeth and Cavitations


Part Ten: Creating a Treatment Plan

Chapter 68 Health and Wellness Monitoring

Chapter 69 Important Wellness Strategies

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